Selected Publications

Role of Diagnostics in Epidemiology, Management, Surveillance, and Control of Leptospirosis.

Jane E. Sykes, Krystle L. Reagan, Jarlath E. Nally, Renee L. Galloway, and David A. Haake.

Pathogens, volume 11(4): 395, March 24, 2022.

Pathogenesis insights from an ancient and ubiquitous spirochete.

Jenifer Coburn, Mathieu Picardeau, Christopher W Woods, Timothy Veldman, and David A. Haake.

PLoS Pathogens, 17(10):e1009836, October 21, 2021.

Leptospiral Immunoglobulin-Like Domain Proteins: Roles in Virulence and Immunity.

David A. Haake and James Matsunaga.

Frontiers in Immunology, volume 11: 579907, January 8, 2021.

cis-Acting Determinant Limiting Expression of Sphingomyelinase Gene sph2 in Leptospira interrogans, Identified with a gfp Reporter Plasmid.

James Matsunaga and David A. Haake.

Applied and Environmental Microbiology, 84(23):e02068-18, November 15, 2018.

LipL21 lipoprotein binding to peptidoglycan enables Leptospira interrogans to escape NOD1 and NOD2 recognition.

Gwenn Ratet, Ignacio Santecchia, Martine Fanton d’Andon, Frédérique Vernel-Pauillac, Richard Wheeler, Pascal Lenormand, Frédéric Fischer, Pierre Lechat, David A. Haake, Mathieu Picardeau, Ivo G. Boneca, Catherine Werts.

PLoS Pathogens, 13:e1006725, December 6, 2017.

Spirochetal Lipoproteins in Pathogenesis & Immunity

David Haake & Wolfram Zückert

Current Topics in Microbiology & Immunology, December 2, 2017.  PMID: 29196824.

High-throughput parallel sequencing to measure fitness of Leptospira interrogans transposon insertion mutants during acute infection

Kristel Lourdault, James Matsunaga, David A. Haake.

PLoS Neglected Tropical Diseases, volume 10, e0005117, November, 2016.

What makes a bacterial species pathogenic?: Comparative genomic analysis of the genus Leptospira

Derrick E. Fouts, Michael A. Matthias, Haritha Adhikarla, Ben Adler, Luciane Amorim-Santos, Douglas E. Berg, Dieter Bulach, Alejandro Buschiazzo, Yung-Fu Chang, Renee L. Galloway, David A. Haake, et al.

PLoS Neglected Tropical Diseases, volume 10, e0004403, February, 2016.

Role of sph2 Gene Regulation in Hemolytic and Sphingomyelinase Activities Produced by Leptospira interrogans

Suneel A. Narayanavari, Kristel Lourdault, Manjula Sritharan, David A. Haake, and James Matsunaga.
PLoS Neglected Tropical Diseases, volume 9: e0003952, August 14, 2015.

Leptospirosis in Humans

David A. Haake & Paul N. Levett.
Current Topics in Microbiology & Immunology, volume 387, pages 65-97, May, 2015.

The Leptospiral Outer Membrane

David A. Haake and Wolfram R. Zückert
Current Topics in Microbiology & Immunology, volume 387, pages 187-221, May, 2015.

Kinetics of Leptospira interrogans Infection in Hamsters after Intradermal and Subcutaneous Challenge

Mariana L. Coutinho, James Matsunaga, Long-Chieh Wang, Alejandro de la Peña Moctezuma, Michael S. Lewis, Jane T. Babbitt, Jose Antonio G. Aleixo & David A. Haake. 
PLoS Neglected Tropical Diseases, volume 8(11): e3307, November 20, 2014.

Oral immunization with Escherichia coli expressing a lipidated form of LigA protects hamsters against challenge with Leptospira interrogans serovar Copenhageni

Kristel Lourdault, Long-Chieh Wang, Ana Vieira, James Matsunaga, Rita Melo, Michael S. Lewis, David A. Haake, and Maria Gomes-Solecki
Infection & Immunity, volume 82, pages 893-902, February, 2014.

Role for cis-acting RNA sequences in the temperature-dependent expression of the multiadhesive Lig proteins in Leptospira interrogans

James Matsunaga, Paula J. Schlax and David A. Haake
Journal of Bacteriology, volume 195, pages 5092-5101, November, 2013.

LipL32 is a subsurface lipoprotein of Leptospira interrogans: Presentation of new data and reevaluation of previous studies

Marija Pinne & David A. Haake
PLoS ONE volume 8, e51025, 2013.

Leptospiral outer membrane protein microarray, a novel approach to identification of host ligand-binding proteins.

Marija Pinne, James Matsunaga, and David A. Haake. 
Journal of Bacteriology, volume 194, pages 6074-87, November, 2012.

FlaA Proteins in Leptospira interrogans are essential for motility and virulence but are not required for formation of the flagellum sheath

Ambrose Lambert, Mathieu Picardeau, Davd A. Haake, Rasana W. Sermswan, Amporn Srikram, Ben Adler and Gerald A. Murray
Infection & Immunity, volume 80, pages 2019-2025, June, 2012.

Multiple leptospiral sphingomyelinases (or are there?)

Suneel Narayanavari, Manjula Sritharan, David A. Haake, and James Matsunaga
Microbiology, published 15, March 2012.

Three-Dimensional Structures of Pathogenic and Saprophytic Leptospira Revealed by Cryo-Electron Tomography

Gianmarco Raddi, Dustin R. Morado, Jie Yan, David A. Haake, X. Frank Yang, and Jun Liu
Journal of Bacteriology, published 6 January 2012.

A LigA Three-Domain Region Protects Hamsters from Lethal Infection by Leptospira interrogans.

Mariana L. Coutinho, Henry A. Choy, Melissa M. Kelley, James Matsunaga, Jane T. Babbitt, Michael S. Lewis, Jose Antonio G. Aleixo, & David A. Haake. 
PLoS Neglected Tropical Diseases, 2011 December; 5(12): e1422.

Methylation and in vivo expression of the surface-exposed Leptospira interrogans outer membrane protein OmpL32.

Azad Eshghi, Marija Pinne, David A. Haake, Richard L. Zuerner, Ami Frank and Caroline E Cameron
Microbiology, December, 2011

Immunofluorescence Assay of Leptospiral Surface-Exposed Proteins

Marija Pinne & David A. Haake. 
Journal of Visualized Experiments, Volume 53, e2805, July, 2011.

Leptospira: a spirochaete with a hybrid outer membrane.

David A. Haake & James Matsunaga. 
Molecular Microbiology, volume 77, pages 805-814, August, 2010.