Recent Publications

Click on the image or title for a link to the paper.


High-throughput parallel sequencing to measure fitness of Leptospira interrogans transposon insertion mutants during acute infection

Kristel Lourdault, James Matsunaga, David A. Haake

PLoS Neglected Tropical Diseases, volume 10, e0005117, November, 2016.


What makes a bacterial species pathogenic?: Comparative genomic analysis of the genus Leptospira

Derrick E. Fouts, Michael A. Matthias, Haritha Adhikarla, Ben Adler, Luciane Amorim-Santos, Douglas E. Berg, Dieter Bulach, Alejandro Buschiazzo, Yung-Fu Chang, Renee L. Galloway, David A. Haake, et al.

PLoS Neglected Tropical Diseases, volume 10, e0004403, February, 2016.


Intracellular bacterial communities: A potential etiology for chronic lower urinary tract symptoms

Victoria Scott, David Haake, Bernard Churchill, Sheryl Justice, and Ja-Hong Kim. 
Urology, volume 86, pages 425-31, September, 2015.


Role of sph2 Gene Regulation in Hemolytic and Sphingomyelinase Activities Produced by Leptospira interrogans

Suneel A. Narayanavari, Kristel Lourdault, Manjula Sritharan, David A. Haake, and James Matsunaga.
PLoS Neglected Tropical Diseases, volume 9: e0003952, August 14, 2015.


Leptospirosis in Humans

David A. Haake & Paul N. Levett.
Current Topics in Microbiology & Immunology, volume 387, pages 65-97, May, 2015.


The Leptospiral Outer Membrane

David A. Haake and Wolfram R. Zückert
Current Topics in Microbiology & Immunology, volume 387, pages 187-221, May, 2015.


Kinetics of Leptospira interrogans Infection in Hamsters after Intradermal and Subcutaneous Challenge

Mariana L. Coutinho, James Matsunaga, Long-Chieh Wang, Alejandro de la Peña Moctezuma, Michael S. Lewis, Jane T. Babbitt, Jose Antonio G. Aleixo & David A. Haake. 
PLoS Neglected Tropical Diseases, volume 8(11): e3307, November 20, 2014.


Emerging Technologies for Rapid Identification of Bloodstream Pathogens

Atul Kothari, Margie Morgan, and David A. Haake
Clinical Infectious Diseases, April 24, 2014.


Oral immunization with Escherichia coli expressing a lipidated form of LigA protects hamsters against challenge with Leptospira interrogans serovar Copenhageni

Kristel Lourdault, Long-Chieh Wang, Ana Vieira, James Matsunaga, Rita Melo, Michael S. Lewis, David A. Haake, and Maria Gomes-Solecki
Infection & Immunity, volume 82, pages 893-902, February, 2014.


Role for cis-acting RNA sequences in the temperature-dependent expression of the multiadhesive Lig proteins in Leptospira interrogans

James Matsunaga, Paula J. Schlax and David A. Haake
Journal of Bacteriology, volume 195, pages 5092-5101, November, 2013.


Bacterial detection & identification using electrochemical sensors

Colin Halford, Vincent Gau, Bernard M. Churchill and David A. Haake
Journal of Visualized Experiments, volume 74, e4282, March, 2013.


Rapid antimicrobial susceptibility testing by sensitive detection of precursor rRNA using a novel electrochemical biosensing platform

Colin Halford, Rodrigo Gonzalez, Susana Campuzano, Bo Hu, Jane T. Babbitt, Jun Liu, Joseph Wang, Bernard M. Churchill and David A. Haake
Antimicrobial Agents and Chemotherapy, volume 57, pages 936-943, February, 2013.


Leptospiral outer membrane protein microarray, a novel approach to identification of host ligand-binding proteins.

Marija Pinne, James Matsunaga, and David A. Haake. 
Journal of Bacteriology, volume 194, pages 6074-87, November, 2012.


FlaA Proteins in Leptospira interrogans are essential for motility and virulence but are not required for formation of the flagellum sheath

Ambrose Lambert, Mathieu Picardeau, Davd A. Haake, Rasana W. Sermswan, Amporn Srikram, Ben Adler and Gerald A. Murray
Infection & Immunity, volume 80, pages 2019-2025, June, 2012.


Multiple leptospiral sphingomyelinases (or are there?)

Suneel Narayanavari, Manjula Sritharan, David A. Haake, and James Matsunaga
Microbiology, published 15, March 2012.


Three-Dimensional Structures of Pathogenic and Saprophytic Leptospira Revealed by Cryo-Electron Tomography

Gianmarco Raddi, Dustin R. Morado, Jie Yan, David A. Haake, X. Frank Yang, and Jun Liu
Journal of Bacteriology, published 6 January 2012.


A LigA Three-Domain Region Protects Hamsters from Lethal Infection by Leptospira interrogans.

Mariana L. Coutinho, Henry A. Choy, Melissa M. Kelley, James Matsunaga, Jane T. Babbitt, Michael S. Lewis, Jose Antonio G. Aleixo, & David A. Haake. 
PLoS Neglected Tropical Diseases, 2011 December; 5(12): e1422.


Methylation and in vivo expression of the surface-exposed Leptospira interrogans outer membrane protein OmpL32.

Azad Eshghi, Marija Pinne, David A. Haake, Richard L. Zuerner, Ami Frank and Caroline E Cameron
Microbiology, December, 2011


Target Specific Capture Enhances Sensitivity of Electrochemical Detection of Bacterial Pathogens.

Mayank Patel, Rodrigo Gonzalez, Colin Halford, Michael A. Lewinski, Elliot M. Landaw, Bernard M. Churchill, & David A. Haake. 
Journal of Clinical Microbiology, Volume 49, 4293-4296, December, 2011.


Highly sensitive disposable nucleic acid biosensors for direct bioelectronic detection in raw biological samples.

Filiz Kuralaya, Susana Campuzanoa, David A. Haake, & Joseph Wang. 
Talanta, Volume 85, 1330-1337, September, 2011.


Immunofluorescence Assay of Leptospiral Surface-Exposed Proteins

Marija Pinne & David A. Haake. 
Journal of Visualized Experiments, Volume 53, e2805, July, 2011.


Heterologous expression of pathogen-specific genes ligA and ligB in the saprophyte Leptospira biflexa confers enhanced adhesion to cultured cells and fibronectin.

Cláudio Pereira Figueira, Julio Croda, Henry A Choy, David A Haake, Mitermayer G Reis, Albert I Ko & Mathieu Picardeau. 
BMC Microbiology, Volume 11, page 129, June, 2011.


Ternary monolayers as DNA recognition interfaces for direct and sensitive electrochemical detection in untreated clinical samples.

Susana Campuzano, Filiz Kuralay, M. Jesús Lobo-Castañón, Martin Bartošík, Kedar Vyavahare, Emil Paleček, David A. Haake, & Joseph Wang.
Biosensors and Bioelectronics, volume 26, pages 3577-3583, April, 2011.


Redox cycling amplified electrochemical detection of DNA hybridization: application to pathogen E. coli bacterial RNA.

Anne Walter, Jie Wu, Gerd-Uwe Flechsig, David A. Haake, and Joseph Wang
Analytica Chimica Acta, volume 689, pages 29–33, March, 2011.


The multifunctional LigB adhesin binds homeostatic proteins with potential roles in cutaneous infection by pathogenic Leptospira interrogans.

Henry A. Choy, Melissa M. Kelley, Julio Croda, James Matsunaga, Jane T. Babbitt, Albert I. Ko, Mathieu Picardeau, & David A. Haake. 
PLoS ONE, volume 6, e16879, February, 2011.


Leptospira: a spirochaete with a hybrid outer membrane.

David A. Haake & James Matsunaga. 
Molecular Microbiology, volume 77, pages 805–814, August, 2010.